Eli Lilly and Company the Global Pharmaceutical Company Essay Example

Eli Lilly and Company: the Global Pharmaceutical Company Paper Analysis Methods Porters Five Force in relation to Eli Lilly Threat of New Entrants Threat of new entrants is relatively high. Companies forming alliances are potential rivals. Even if earlier such company was not considered to be a threat, after merging with some research and development company or forming alliance with another pharmaceutical company it would become a rival to Eli Lilly. The threat is however weakened by significant research and development costs necessary to successfully enter the business. Eli Lilly’s focus on a relatively narrow market of sedatives and antidepressants weakens the threat of new entrants, but other products that form lesser part of company’s sales such as insulin and others are exposed to high threat of new entrants. The need of obtaining certificates and licenses also weakens the threat of new entrants. Discussed above leads to the conclusion that threat of new entrants is medium. Bargaining Power of Buyers It tends to be high in pharmaceutical business as main sales are done using whole sales. Institutions that purchase drugs in large quantities are considering the discounts that drug producers are willing to give and therefore are able to influence price. As long as Eli Lilly have competitors with similar products it is obvious that bargaining power of buyers is high for the industry. Buyers with smaller volumes of purchases do not influence price policy, but such buyers are outnumbered by wholesale buyers. It is also important that people purchasing drugs for themselves are usually covered by healthcare insurance and therefore are not interested in pulling price down. We will write a custom essay sample on Eli Lilly and Company: the Global Pharmaceutical Company specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on Eli Lilly and Company: the Global Pharmaceutical Company specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on Eli Lilly and Company: the Global Pharmaceutical Company specifically for you FOR ONLY $16.38 $13.9/page Hire Writer Yet the volumes of sales to such buyers are not significant. Bargaining Power of Suppliers It is relatively not high. There exists possibility to switch supplier at low cost and supplier brands are not powerful. There exists a little possibility of forward integration. All of the above makes the bargaining power of supplier low. In Eli Lilly’s case it is true that the power of suppliers is reversal of the buyer’s power. Threat of Substitute Product The threat of substitutes is not very high. Traditional medicine using drugs as a curing remedy is a main mean for treatment used by almost all healthcare institutions. Substitutes such as sport, yoga, alternative medicine are not very popular and unlikely to become such. However for the main product Prozac, which is an antidepressant drug, alternatives are possible because treating depression using alternative medicine, psychologist’s help and other means is more probable than treating of physical disease by similar means. The threat of substitutes is low, which is a significant advantage Rivalry Among Competitors The rivalry is tense in this business. However the competitiveness is rather unique in pharmaceutics. High costs of research and development hold the appearance of new rivals. It is also true that rivals are usually focused on a rather small market of specific medication. The main rivals Novo Nordisk A/S, Pfizer and Smithkline are narrowly oriented companies which however give Eli Lillys hard time producing such products as Zoloft – Prozac alternative. The competitive rivalry in the business is medium. SWOT MATRIX STRENGTHS-OPPORTUNITIES 1Eli Lilly Company should join strategic alliance to develop and market a blood substitute product on its ethical products. 2Use cooperation joint ventures alliance3s to lower down costs of R expenditures, increase research capabilities and seize economies of scale, thereby protecting future profits. 3Offer wide spectrums of products 4Make research in other therapeutic benefits from a previously marketed drug. 5Identify and develop treatments for future wide spread maladies. STRENGTHS-THREATS Find innovative ways to extend patent on Prozac through marketing it in other forms. WEAKNESS-OPPORTUNITIES 1Consider joint ventures and alliances with generic-producing pharmaceutical to protect earnings from patent losses. 2Make research on the pricing policy in other markets around the globe to make wise market entry decisions. WEAKNESS-THREATS 1Find creative ways to extend patent protection and differentiate it from those of competitors by creating a bra nd name and customer loyalty. SWOT ANALYSIS Strengths 1. Success of their anti-depressant Prozac 2. Many Strategic Alliances 3. Patent protection of company’s products 4. Heavily involved in Alliances to perform research 5. Top 10 contender in the Pharmaceutical Industry 6. 1st pharmaceutical firm to market a genetically engineered drug the Humulin 7. Pharmaceutical products are widely distributed in 200 dependent wholesale outlets in U. S. 8. It had R D facilities in 9 countries including North America, Europe, and Japan 9. It had manufacturing facilities in 20 countries including locations in Australia, South America, China, Middle East, Europe in U. S. Weaknesses 1. Unfavorable exchange rates in overseas sales 2. Decline of sales of anti-infective due to strong competition from generics in the U. S. and overseas Opportunities 1. U. S. market offering great growth potential 2. Trends of globalization 3. Aging of worldwide population 4. Longer life expectancy 5. Opening of new markets 6. Increased demand from Third World nation experiencing rising standards of living 7. Merge agreement with Sepracor Threats 1. Expiration of Prozac patent 2. Emergence of Generic Drugs 3. Under investigation by the Federal Trade Commission (FTC) for alleged antitrust activity due to its agreement with Sepracor 4. Unresolved case with Barr Laboratories, Inc. from manufacturing generic versions of Prozac 5. Lawsuit with Zeneca Inc. regarding its product Evista claiming that it is a breast cancer treatment 6. Market outside U. S. are less attractive with socialist governments and price controls INDUSTRY ANALYSIS The industry consists of the product organizations such as drug companies and product and supplies organizations. The size of the global industry was $250 billion in 1999 and 6 to 7 percent annual worldwide sales growth for 1999 to 2003. The pharmaceutical industry ranks as the number one industry in the world in terms of return on assets, return on revenue and number three in terms of return on equity for year 1997 among Fortune 500 companies. Among the 14 pharmaceutical companies in the Fortune 500 for 1997, Merck was ranked 1st, Pfizer 5th, Abbot 6th, and Eli Lilly 7th in terms of revenues. Rivalry among competitors is intense as brand recognition has become increasingly important as an approach to capturing market share. Companies are increasing advertising budgets to promote the therapeutic benefits of their drugs in an effort to differentiate their products from competitors. Many existing pharmaceutical compounds are standardized formulations that vary little in efficacy among manufacturers. The search for a differentiated product that will lead to blockbuster sales is one reason R D, advertising and sales force budgets have increased in recent years. Risk is high in the pharmaceutical industry as expenditures for research and development for each drug typically last through a period of 10 to 15 years before a compound makes it to the market. FDA approvals generally take 16 months which is down from 32 months in 1987. It is very unlikely that a compound developed by a pharmaceutical company will ever be used in the retail market. Only 1 in 5000 compounds will eventually be sold and less than one third of all marketed drugs will provide a return to recoup R D expenditures. The average costs associated with bringing a drug to market is $500 million while the product life of a prescription drug averages 10 years. There are several underlying trends in the world that are contributing to the demand for pharmaceutical drugs. The aging of the baby boom generation and increasing life expectancy rates are expected to increase the demand for prescription drugs over the next 25 years. The number of people between 45 and 64 years old will increase 41% by 2015. Given the rise in age population and life expectancy rates around the world and the level of pharmaceutical use by aging individuals, growth in the industry should remain in an upward trend. The pharmaceutical industry is relatively immune from the effects of economic cycles. Demand for the industrys product remains constant in up and down economic cycles as market demand is a function of the overall health of the population. However the globalization of the pharmaceutical industry increases the risk associated with foreign investments and exchange rates. The firms in this industry seek to minimize risks by using hedging practices such as foreign currency forward-exchange contracts, borrowing in foreign markets, and using currency swaps.

A Clockwork Orange - review essays

A Clockwork Orange - review essays Whats it going to be then, eh? the opening line of Anthony Burgess A Clockwork Orange, being the adventures of a young man whose principal interests are rape, ultra-violence and Beethoven. In the story, we are introduced to young Alex and his droogs, who like nothing more than lashings of the old ultraviolence. It is Alex who commits their first murder, and after being betrayed for droog-related political reasons, is sent to jail. Through a new controversial rehabilitation treatment, designed to curb violence and sexual behaviour, the state uses our unlikely hero as their guinea pig. The experiment is a success (I use this word loosely), Alex begins to feel physically repulsed by violence of any sort, and as a side effect, also to Beethoven. He will not commit crime, but he has also deprived of the capacity to chose not to. This leads us to the central point of the novel, concerned with free will: Do we lose our humanity if we are deprived the choice between good and evil? Burgess skilfully introduces us to his futuristic slang, or nadsat, making A Clockwork Orange valuable not only for the questions it raises, but also for its creative and experimental use of the English language in which we see hints of Russian. This is no fluke. What perhaps makes the novel so good is that each word Burgess uses has been chosen intentionally. Stanley Kubricks film version is cannot be left unmentioned, it is, in fact, a masterpiece. Being very faithful to the text, its violent scenes still shock us 30 years on. But perhaps the most interesting thing about the film is that its ending is different to that of the book: chapter 21 is left out. I would agree with many critics in saying that this changes the whole mood of the story. In the book we see Alexs character maturing, putting his old self behind him by choice, while the film shows Alex regressing to his former self. This has...

Euro Essay Example | Topics and Well Written Essays - 250 words

Euro - Essay Example They introduced the Euro in non-physical electronic form at midnight on 1 January 1999. At that time, the national currencies of participating countries ceased to exist. Nevertheless, they continued as legal tender until new euro notes and coins were introduced on 1 January 2002. The changeover period lasted until 28 February 2002. The purpose of the Euro was to solidify the European economy as a whole (Gerlach and Svensson 2003). Differences cause by rounding and the use of significant digits made international trade difficult on the subcontinent itself. Plus, the institution of a unified mode of exchange augmented trade outside Europe. As a result, the European economy has become stronger both internally and externally. Compare the performance of the Euro to the U.S. dollar, for instance (Portes et al 1998). From the start, the Euro represented about one and a half times the value of the U.S. dollar. Although it has risen and fallen over the last decade, it has always remained competitive and never sunk below the value of a U.S. dollar. This indicates a robust global presence on part of the Euro. It will be interesting to observe the impact of the Euro on stabilizing our current global recession. References and further reading may be available for this article. To view references and further reading you must purchase this article. Stefan Gerlach and Lars E. O. Svensson.  Journal of Monetary Economics, Vol. 50, No. 8, November 2003, pp.

Sport clothing Essay Example | Topics and Well Written Essays - 500 words

Sport clothing - Essay Example According to NoÃŒ voa & DrăGoicea, (2015, p. 207), sport technology represents a specific type of means to recognize human interests and aims in sport. Sport technology can also refer to the ways in which athletes tend to improve their training in a competitive environment for them to enhance their overall performance. Use of technology in sports involves application of knowledge in using specialized equipment and tools and making use of the available improved technologies to perform tasks more effectively and efficiently. Sporting technologies available include, tennis rackets, pole-vault poles, golf clubs, motion capture, advanced computer stimulations and athletic sports gear such as clothing and footwear. Use of technology in sports is viewable in many perspectives. For instance, technology use exists in the assessment of athletes through biometric sensors, laser-based speed timing and a number of medical technologies. Sports teams and athletes have benefited from the use of technology through better film breakdowns for study, competitive scouting efforts, and statistical reporting. Technology assists in sports competition through instant replays and sensors that help sporting officials decide on whether a ball crosses a line into a goal. This happens in hockey punks and in soccer balls. Fans also benefit in technology through improvements in camera techniques and video display technology (Cremades & Tashman, 2014, p.183). To enhance the athlete’s performance, sports gear such as the clothing and footwear should be friendly and should be of valuable quality in terms of strength thickness, flexibility, durability and resistance to moisture. Footwear is more of a comfort and injury protection wear than a performance enhancing wear in sports. On the contrary, clothing like full body suits streamlines the athletes performance period in a competitive race. Composite tennis racket relates to sporting equipment designed to

Hinduism, buddhism and sikhism Essay Example | Topics and Well Written Essays - 1000 words

Hinduism, buddhism and sikhism - Essay Example his seven dimensions of religion.These are;practical or ritual,experiential or emotional,narrative or mythical,doctrinal or philosophical, legal or ethical,social or institutional and the material/artistic dimensions. In Hinduism, offerings and petitions are practices which enable them to connect to divine powers so as to solve their problems at the same time fulfilling their desires. Similarly, the Buddhist engage in detailed prayers which are intimate to show dedication to God. The Sikhs engage in a disciplined way of life of Naam Simran which is a way to meditate on God’s name. Hindus of all levels in society perform artistic dance, drama, music, poetry and representational arts and also practice cylindrical festivals which are sacred. Buddhas evoke Sangha to spread Buddha teachings after which the dharma students perform three bows or the three gates (body, tongue and mind). The palms of their hands, knees and forehead should touch the ground to signify earth, water, fire, air and space. The Buddha students bow during prayers with folded hands to signify Buddha of the past present and the future. The Sikhs live a disciplined life and no benefits are gained no matter where one is born since they all have to meditate (by reciting Gurbani and Kurtan which are music hymns) and give selfless service (by doing manual work at the Gurdwara e.g. cleaning dishes and floors) and wear Kesh, Kanga, Kaccha, Kara and Kirpan (Llewellyn 6-18). This refers to feelings and experience of various religions which incorporate stories of how their leaders experienced contact with either divine beings or energies. In Hinduism, Hindus assume to be concerned with spiritual enlightenment or the ultimate act of liberation (moksha). The urban elite and the rural Hindus dedicate their time and energy to obtain prosperity. In Buddhism, the most important emotional experience is meditation that enables emotional awareness and enlightenment. For instance, the Buddha connecting with the

Insulin and Predicting Clinical Outcome

Insulin and Predicting Clinical Outcome A. To identify predicting clinical outcome: Predicting clinical outcome in patients with incessant hepatitis C is testing. We utilized the hepatitis C long-term treatment against cirrhosis trial database to create two models, utilizing pattern estimations of routinely accessible research facility tests together with changes in these qualities amid follow-up to foresee clinical decompensation and liver-related demise transplant in patients with cutting edge hepatitis C. b. Identify the inhaled insulin: Inhaled insulin is a type of insulin that can be inhaled into the lungs through utilization of an exceptional inhaler. Breathed in insulin may in some cases be utilized to treat diabetes mellitus. Insulin treatment has advanced since its initiation. At first, we saw changes in its immaculateness, and new details to expand activity time and decline recurrence of infusions. With time and a further comprehension of the need to supplant insulin in a way that imitated ordinary physiology, more current insulins were composed that could achieve this objective all the more viable (Moshe Phillip, 2012). Simultaneously, strategies for insulin conveyance have likewise enhanced, including dispensable syringes, insulin pens, and insulin pumps, all of which have made insulin organization more sensible and more agreeable. c. To identify long-term insulin: Long-acting insulins dont top like short-acting insulins they can control glucose for a whole day. This is like the activity of insulin ordinarily delivered by your pancreas to help control glucose levels between dinners. Long-acting insulins are likewise called basal or foundation insulins. They continue working out of sight to monitor your glucose all through your day by day schedule. d. To identify Diabetes type 1: The more extreme type of diabetes is sort 1, or insulin-subordinate diabetes. Its occasionally called adolescent diabetes, since Type 1 diabetes more often than not creates in kids and young people, however, it can create at any age (Richard I. G. Holt, 2011). With type 1 diabetes, the bodys resistant framework assaults some portion of its pancreas. Researchers dont know why. In any case, the invulnerable framework erroneously observes the insulin-delivering cells in the pancreas as outside and annihilates them. This assault is known as immune system sickness. Conceptual model: Conceptual models in wellbeing training research have been characterized as outlines of proposed causal linkages among an arrangement of ideas accepted to be identified with a specific general medical issue. The calculated models appear the little piece of the causal web chose for study. They frequently are educated by more than one hypothesis, and additionally by exact discoveries. A reasonable model gives a visual picture that speaks to the exploration address which is to be researched. The best models pass on complex data in a way that is miserly as well as grants a speedy handle of confounded connections (Kane, 2006). For instance, a theoretical model can be utilized to portray the different ideas that are important in a specific infection or condition and the speculated interfaces between the ideas, or to give a structure from which potential focuses for treatment can be chosen. A theoretical model can manage our decision of what to quantify and how to gauge it and give a settin g to translating the discoveries. In 1995 Wilson and Cleary distributed a calculated model for wellbeing related personal satisfaction which coordinated both organic and mental parts of wellbeing results. They proposed five unique levels in their model, to be specific physiological elements, side effect status, utilitarian wellbeing, general wellbeing recognitions and general personal satisfaction. They characterized their calculated model as a scientific categorization of patient results as indicated by the fundamental wellbeing ideas they speak to and proposes particular causal connections between various wellbeing ideas. The Wilson-Cleary Conceptual Model of HRQoL is caught in figure 1. As the per user moves from left to right of the model, the nature of the ideas shifts from the cell toward the individual, and afterward to the communication of the person as an individual from society. A conceptual model can be utilized to investigate the patient point of view of a sickness and can help recognize the viewpoints that should be tended. Such theoretical models could be utilized to show the significance and seriousness of patient-focused results for measuring treatment benefits in a particular infection or condition. They would be particularly valuable for exchanges with administrative organizations about treatment advantage claims given patient, detailed results. Conceptual model for Clinical Outcomes and Response to combination of rapid-acting inhaled insulin with long-acting injectable insulin in patients with diabetes type 1.   Ã‚   Key dependent and independent variables: Variable is a term as often as possible utilized as a part of research activities. It is applicable to characterize and recognize the factors while outlining quantitative research ventures. A variable induces fervor in any explore than constants. It is in this way basic for amateurs in research to have lucidity about this term and the related ideas. Independent variable: The independent variable is the forunner while the destitute variable is the resulting. In case the self-governing variable is a dynamic variable then we control the estimations of the variable to study its impact on another variable. In the above case, we change pressure level to check whether responsiveness to torment diminishes medication is updated. Uneasiness level is the self-sufficient element variable. Dependent variable: The dependent changeable is the variable that is partial through the free factor. Receptiveness to anguish lessening drug is the district changeable in the beyond illustration. The area changeable is dependent on the autonomous variable. The operational definition of the key variable: An operational definition, when associated with data social occasion, is an unmistakable, compact point by point significance of a measure. The prerequisite for operational definitions is significant when assembling an extensive variety of data. It is particularly basic when a decision is being made about whether something is correct or off course, or when a visual check is being made where there is space for perplexity (Tracey D. Matthews, 2011). Clearly, the operational meaning of the reliant variable is an essential stride in the outline of the review. Some other wellbeing related applied factors that have numerous operational definitions: insight, wellness, wellbeing, personal satisfaction. A few polls have been produced to quantify these theoretical factors. In an exploration article, the operational definition is typically found in the strategies section. Operational definition in the variable table it is used in health research. Analyze the threats for research: In medical studies, viability thinks about in test settings are directed to address the issue of inward legitimacy while adequacy ponders in naturalistic settings are utilized to look at the outer legitimacy of the claim. Normally patients in experimentation are exceptionally chosen though patients in this present reality are most certainly not. For instance, subjects in clinical trials, for the most part, have quite recently the sickness under review. Patients who have various wellbeing conditions are rejected from the review because those uncontrolled factors could jumble the research result. In the research of Predicting Clinical Outcomes and Response to a combination of rapid-acting inhaled insulin with long-acting injectable insulin in patients with diabetes type 1 two types of threats are produced one is internal threats, and other is external threats. Internal legitimacy implies especially to whether an exploratory treatment/condition has any impact on the outcome or not, and whether there is satisfactory confirmation to substantiate the claim. Outer legitimacy insinuates the generalizability of the treatment/condition comes about across over various settings (STEVEN TAYLOR, 2007). Internal legitimacy is how much changes in a dependent variable can be attributed to changes in a self-sufficient variable. In this manner, inward legitimacy involves degree instead of one of nearness or nonappearance. The scientists trust in his or her discoveries is proportionate to the quality of inward legitimacy of the examination plan . Genuine tests are outlines that have solid inward legitimacy. That is individuals are randomized to test conditions, and distinctive means are used to ensure that changes in the Reliant variable can be credited to the trial control of the self-sufficient variable. Eight dangers to inward legitimacy have been descri bed:history, development, test, instrumentation, relapse, determination, exploratory mortality, and a cooperation of dangers. History: History turns into hazard when dissimilar basics external to the subject happen by uprightness of the series of time. Development: The advancement hazard can work when natural or mental changes occur inside subjects, and these movements may record to some degree or all together for effects saw in the survey. For example, a point by point decreasing in emergency room visits in a whole deal examination of pediatric patients with asthma may be a direct result of surpassing youth asthma rather than any treatment regimen constrained. Testing: The testing danger may happen when changes in test scores happen not therefore of the intervention yet rather in light of reiterated testing. This is of particular concern when examiners coordinate vague pretests and posttests. Regression: The regression hazard can occur when the outrageous score has selected subject since extraordinary scores inside a conveyance tend toward sketch earlier to the mean in rehash test. Differential Selection: The assurance hazard is of most extraordinary concern when subjects cant be subjectively doled out to treatment groups, particularly if social events are unequal inapplicable elements before treatment intervention. Diffusion or Imitation of Treatments: When members in the diverse exploratory conditions can speak with each other, to such an extent that members in one condition find out about what occurs in the other condition. This can undermine the contrasts between the exploratory controls in each condition. Example. In an investigation of the impacts of weight on snake fears, wind frightful undergrad brain research understudies were haphazardly relegated to one of two groups. Testing: The reactive impacts of testing where the very demonstration of appraisal impacts the variable under scrutiny. A few measures are exceedingly receptive, while different measures are inert. Likewise, rehashed testing can increment recognition with the test, which may predisposition scores. This risk can be managed in different courses, for example, by choosing inert measures or, on the other hand by counting a control aggregate. Selection: When the effects on the dependent variable emerge from contrasts in the sorts of individuals in the test bunches. Choice impacts are unavoidable in semi-exploratory outlines. These are among the most broadly utilized plans in clinical brain science, in which an objective gathering is thought about with at least one control bunches. Endeavors are made to coordinate the bunches on foundation factors, and after that, they are looked at on the factors of intrigue. External validity needs to do with the generalizability of the examination discoveries; to what degree can the discoveries of analysis or quasiexperimental be summed up to and crosswise over different populaces, settings, and ages? In the accompanying segments, we look at, in further detail, the significant sorts of dangers to outside legitimacy, the connection amongst inside and outer legitimacy, and the circumstances in which we ought to be worried about dangers to outer legitimacy. Dangers to outer legitimacy are assessed by the trial of the degree to which one can sum up crosswise over different sorts of individuals, settings, whats more, times and are, fundamentally, the trial of factual cooperations. Analysis plan of the research project: An analysis plan helps you thoroughly consider the information you will gather, what you will utilize it for, and how you will examine it. Making an investigation plan is a vital approach to guarantee that you gather every one of the information you require and that you utilize every one of the information you gather. Investigation arranging can be a precious speculation of time. It can help you select the most suitable research techniques and measurable instruments. It will guarantee that the way you gather your information and structure your database will help you get a solid analytic result. In this research paper, many people include in the research project. In this research project, different types of diseases include such as diabetes, insulin, and long term insulin and so on. In this paper, many people are injected with diabetes, and some individuals are injected with insulin. We find that diabetes is two types type 1 diabetes and type 2 diabetes. We find the data of patients which is injected to this problem. Data collection is a very important step for this research paper. Firstly we collect the data and after that take steps to control it. In this research for diseases use the conceptual model. Conceptual models in wellbeing training research have been characterized as outlines of proposed causal linkages among an arrangement of ideas accepted to be identified with a specific general medical issue. The calculated models appear the little piece of the causal web chose for study. The research project includes the operational definition for prevention the diseases. It connected to information gathering, is an unmistakable, succinct point by point meaning of a measure. The requirement for operational definitions is major when gathering a wide range of information. This is the research project paper for Predicting Clinical Outcomes and Response to a combination of rapid-acting inhaled insulin with long-acting injectable insulin in patients with diabetes type 1. References Kane, R. L. (Ed.). (2006). Understanding Health Care Outcomes Research. Jones Bartlett Learning. Moshe Phillip, T. B. (2012). ATTD 2011 Year Book: Advanced Technologies and Treatments for Diabetes. John Wiley Sons. Richard I. G. Holt, C. C. (Ed.). (2011). Textbook of Diabetes. John Wiley Sons. STEVEN TAYLOR, G. J. (2007). INTERNAL AND EXTERNAL VALIDITY IN CLINICAL RESEARCH. 12. Tracey D. Matthews, K. T. (2011). Designing and Conducting Research in Health and Human Performance. John Wiley Sons.

Chemical Kinetics: Enzymes Essay -- Chemical Kinetics: Enzymes

Chemical Kinetics is the branch of chemistry that studies the speed at which a chemical reaction occur and the factor that influence this speed. What is meant by the speed of a reaction is the rate at which the concentrations of reactants and products change within a time period. Some reactions occur almost instantaneously, while others take days or years. Chemical kinetics understanding I used in the process of designing drugs, controlling pollution and the processing of food. Most of the time chemical kinetics is used to speed or to increase the rate of a reaction rather than to maximize the amount of product. The rate of a reaction is often expressed in terms of change in concentration (Δ [ ]) per unit of time (Δ t). We can measure the rate of a reaction by monitoring either the decrease in concentration (molarity) of the reactant or the increase in the product concentration. Considering the following hypothetical reaction: A 2B Where A molecules are being converted to B molecules, we can say that the rate of this reaction would be: _ Δ [A] (with respect to the decrease in A concentration) Δ t 1 Δ [B] (with respect to the increase in B concentration) 2 Δ t Many factors influence rates of chemical reactions. Some of these factors include: the nature of reactants, for example the formation of salts, acid-base reactions, and exchange of ions are fast reactions, while in reactions where bigger molecules are formed or break apart are typically slow; temperature, frequently, the higher the temperature, the faster the reaction; concentration effect, the reliance of reaction rates on concentrations are called rate laws. Rate laws are expressions of rates in terms of the concentra... ...t being the only target of these enzymes they also make changes retinol, steroids, and fatty acids. The collection of different kinds of alcohol dehydrogenase guarantees that there will always be one that is just perfect for the each task. This enzyme size is 80,000 g/mol, its charge is pI = 5.4, and it optimal pH I 8.6. Works Cited 1. ADH. http://bio.chem.niu.edu/Chem570/Templates/ADH/ 2. Alcohol Dehydrogenase. http://florey.biosci.uq.oz.au/Html/Images/Galleria/dulley/text.html 3. Alcohol Dehydrogenase. http://www.lmcp.jussieu.fr/iucr-top/comm/cteach/pamphlets/15/node30.html 4. Worthington Price List. Alcohol Dehydrogenase http://www.worthington-biochem.com/priceList/A/AlcoholD.html http://www.mssc.edu/biology/B305/GTS/ss98/cjd/alcoholdh.htm http://www.uni-saarland.de/~mkiefer/coenz.htm http://www.chm.davidson.edu/vce/kinetics/ReactionRates.html

Albany Plan of Union Essay

A lot of uneducated people in today’s time think that the colonies always worked together before the French and Indian war. But sadly the people who think this are wrong. In fact the only connection between the colonies, other than the fact that they were all part of England, was through trade. With this loose connection there would never be any hope of defeating the French in the French and Indian war. But luckily Ben Franklin had a great idea to unite the colonies called the Albany plan of union. Even though it was not passed, the Albany Plan of union was a genius idea because it brought every colony under the control of one council, allowed the collection of taxes for military purposes, and united the colonies so that they could actually defeat the French. First off, throughout America the only thing governing the colonies besides England was each colony’s own colonial assembly. This kept each of the colonies very diverse and independent from each other. With the Albany Plan each of the colonies would be under control of a Grand Council, which would be headed by a President General appointed by the king. This would keep all the Colonies together and following one order. With this the Colonies could easy be ready for war if anything were to happen. Secondly, another big problem with the separated colonies was the fact that barely any money was sent to help the war effort. Without money for support there would be no way for supplies. Under the Albany Plan for Union, the grand council would have the right to collect taxes to go towards the war effort. One of the disagreements about this part of the plan was that the larger colonies became angry because they would be paying more taxes then the smaller colonies. This would prove to be Benjamin Franklin’s most daring part of his plan. Finally, one of the most important parts of this plan was that it united all the colonies as one. Before this plan the militia was state based and not very professional. Also state militia would not leave the boundary of their own state. This made the Militia weak and unable to defeat the French. With this union of colonies, the militias could come to the war in minutes earning them the nickname, Minutemen. In conclusion, The Albany Plan of Union was truly a genius idea. Each part f the plan was what the colonies needed to be united and to defeat the French forces. Sadly though, The Albany Plan of Union needed an approval from parliament and the colonial assemblies. In the end it was not passed because the British saw it as a threat and the Assemblies liked there power. Even though it was not accepted it was a great idea. Even though it was not passed, the Albany Plan of union was a genius idea because it brought every colony under the control of one council, allowed the collection of taxes for military purposes, and united the colonies so that they could actually defeat the French.

buy custom Boston Massacre essay

buy custom Boston Massacre essay The Boston Massacre expressed the peoples discontent at the kind of rules that the colonialists wanted to implement in America. It was also called the the bloody massacre in the King Street and the state street massacre. The street shooting that led to the loss of human lives was such a dramatic occurrence that caused the American Revolution. The massacre has sparked a lot of debate on the person or authority to be held liable for the bloody killing, whether it was the soldiers who violated the colony laws, which ruled out firing at the people, or the civilians who insulted the soldiers.Therefore, the research focuses on the background of issues leading to the confrontation, an account of the event, trial, and aftermath of the event, then a conclusion. Despite the position taken regarding an individuals views, the Boston Massacre is still considered a typical landmark of the American Revolution. Background The Boston massacre occurred on 5th march, 1770 when the British regulars murdered five Bostonians in the confrontation that occurred on the King Street.Typically, the killings resulted from the tension that the appearance of the royal troops in Massachusetts had caused. Notably, the troops presence was to impose the tax burden that the Townshend Act had imposed in the area. Also, they were to restore the British law and order that was deteriorating in the region. As the Americas colonial power, Britain had to ensure that order was maintained and the people had to follow the laws to the latter. The colonial master had to deal with the apparent difficulties that the soldiers had to go through. Notably, the soldiers kept on patrolling on King Street and were to maintain peace. Still, there was no abuse of any kind. Moment later, a crowd of people gathered at the street, but, was unarmed. The only notable thing is that they had sticks and were expressing distress at the perceived military roughness in the city.However, there was no call for firearms use. Account of the events The first troops from Britain reached Boston in 1768.Notably, their arrival triggered hostility between the soldiers implementing the Kings rule and the civilians in Boston. Indeed, it was the Boston Importers who ignored the custom duties that they were required to pay, who caused the trouble. Some of the Bostonians were not happy with the soldiers because they were implementing what the people regarded as impressments laws. Under such laws, the civilians could be seized forcefully and incorporated in the British Navy. In discomfort to the rules, clashes began to arise between the civilians and the soldiers. A consequential fight erupted on 2nd March, 1770 between John Grays employees and the soldiers.One employee insulted a soldier, who invited fellow soldiers to retaliate the insult. The fight attracted a large crowd that had similar discomfort, at the manner in which the soldiers did their work. Therefore, the soldiers were forced to use the weapons in defense. The second fight followed a disputed bill that a British officer had failed to settle his bill at a wig-maker shop, located at the King Street.The officer was confronted and forced to pay for the debt. Indeed, the confrontation attracted a large crowd that became hostile, leading to a heavy fight. As the fight continued, another confrontation ensued between Redcoats and the civilians. There was also a third crowd carrying clubs and matching towards the Dock Square. Soldiers tried to repel the crowd that turned violent. Trouble was increasing all around the city and attracted a large crowd that jammed the King Street and became rowdy.The crowd started throwing coal chunks, snowballs and oyster shells at the soldiers. Then, the crowd was ordered to disperse, but turned deaf ears at the call. The crowd intensified their match towards the soldiers and one of them grabbed a soldier and banged him down. In response, the soldier unloaded the musket pointing at the crowd and started firing. Then the soldier shouted fire, and the others joined him in firing at the crowd.Despite firing, the large crowd did not retreat, but, matched to the soldiers. The soldiers continued to fire in response to the jostling crowd. At that time, five civilians died on the street and several others sustained serious injuries. The crowddid not give up due to their determination to fight and the soldiers did not wait. They loaded the guns once more and ready to open fire. This made the captain to shout, Stop firing. The acting governor of the town, Thomas Hutchinson heard the shooting incident while at his home in North Square and rushed to the scene.He found the captain and the angry crowd still at the embattled street. He talked to the captain and asked him, Do you know, sir, you have no power to fire on anybody of the people gathered, except you have a civil magistrate with you to give orders.The captain replied, I was obliged to, to save the sentry.Then governor proceeded to the Town House, where he guaranteed the council members who had gathered that justice would take its course. He also assured the crowd that he would do all to ensure justice is done and asked them to remain calm. The Trials According to Linder, the authority agreed that Captain Preston had to face trial separately from the other eight soldiers. However, the soldiers objected this in a letter that they wrote to the court. The letter stated that, the distressed prisoners begged to be let free to have their trial when Captain Prestons case was being heard. This is because the soldiers carried out orders from the captain, and those who disobeyed the orders could be confined or shot. Linder further stated that, the soldiers feared that Prestons defense lay in refuting that he gave orders to fire, while the soldiers knew that their defense lay in making the claim that they strictly, followed their captains orders. The soldiers knew that if Captain Preston proceeded for trials first, their defense could be compromised. As a result, the conflict that occurred between Preston and the soldiers presented attorney John Adams with a dilemma because he had accepted to defend both parties. According to best practices, John should have made a decision to represent either the eight soldiers or Captain Preston, however, in the 1700s such kind of conflicts were viewed differently. Unfortunately, the soldiers plea to have a joint trial was denied without clarification. Captain Preston was the first person to face trial for murder. The trial lasted for ten days, from October 24th to October 30th at the Queen Street Courthouse. Samuel Quincy who was the solicitor general and Robert Paine a prominent Boston lawyer led the prosecution. John Adams was assisted by Josiah Quincy in defending Preston. The issue during the trial was whether Preston ordered the soldiers to fire civilians. Moreover, Linder asserted that Preston steadfastly denied that he ordered the soldiers to fire the civilians. Three defense witnesses supported Prestons account in denying that he gave orders to fire the civilians while four witnesses supported the prosecution that, indeed, Preston gave the order. Calef Daniel was the only prosecutions eyewitness whose statements were convincing. Daniel claimed that he was present at the firing, and in fact he heard one of the guns rattling. He said further that he turned around, and heard the officer who stood on the right order the soldiers to fire. The officer was wearing a yellow jacket, redcoat, a hat with silver lace, and an untrimmed coat. Daniel swore that he saw his face because the moon was shining Sadly, copies of the trial do not exist even though the trial was written in shorthand. The testimony of Preston was surmised from the evidence that he gave during the advance trial. Preston submitted an account of how some people asked him if the guns were charged and he replied with a yes answer. Conversely, when the same people asked him if he intended to order his men to fire, Preston vehemently denied. Nevertheless, while Preston was still speaking with the civilians, one of the soldiers who had reeceived a blow stepped aside on one side and fired. When Preston turned around to ask the soldier why he had fired, he (Preston) was also struck on the arm with a club. This prevented him from using the arm for sometime, he lamented had the blow found his head it could have destroyed it. He went on saying that the attack was carried out on the civilians by using snowballs and clubs; hence, his life was also in danger. As everyone struggled to get a haven, some of the civilians called on the soldiers to fire. Immediately about four soldiers fired sequentially during the confusion. John Adams doubted the jurors minds, whether Preston ordered the soldiers to fire. The twelve man jury made deliberations for a few hours and finally acquitted Preston of all the charges that were labeled against him. After eight weeks, the soldiers faced trial. The witnesses testified on the clashes between military and civilians on what happened three days before the massacre as well as the events that took place during the night of the massacre. From the prosecutors side, the most damning evidence was that of Samuel Hemmingway who stated that Private Killroy Samuel who had been identified earlier by another witness actually shot John Gray. Killroy could not miss an opportunity to fire the inhabitants because he always wanted to shoot civilians from the first time he arrived. The defense lawyers presented testimonies to support the theory that soldiers merely fired in self-defense. One of the defense witnesses called James Bailey presented a photograph of a rowdy gang. Bailey explained how the soldiers were pelted with chunks of ice and other crude objects. In addition, Bailey testified that he saw Attucks Crispus hit Private Montgomery using a cord wood stick. Adams questioned the jury if they could stand still in such a situation and allow the mob to knock their brains. The Aftermath of Boston Massacre According to Reid Philip, Captain Preston and the four men that were in the Custom House were indicted on the 27th of March. The government gave the soldiers a fair trial so as to prevent retaliation from the British as well as to avert alienation of the moderates from the patriots cause. In defending the soldiers, Adams argued that if the soldiers lives were in danger because of the Negroes, saucy boys, molattoes, jack tarr, and Irish teagues, then the law allowed the soldiers to fight the civilians. Reid further says that John Adams blended eloquence and law in concluding his defense. He told the jury that this was a case of self defense. Justices Oliver and Trowbridge instructed the jury. Trowbridge told the Boston men that, malice distinguishes murder from every other homicide. On the other hand, Oliver asked Carr to determine whether a man who steps into eternity should not be believed, particularly in favor of those who he had lost his life to. Finally, Reid documented that after the deliberations, the six soldiers were acquitted of all the charges, however, Montgomery and Killroy were found guilty for an offense of manslaughter. The two soldiers appeared in court on the 14th of December to give the reason for not being liable for the killings and not face death sentence, they invoked the benefit of clergy. Ultimately the soldiers punishment was turned into thumb branding from imprisonment. The jurys decision was based on the belief that soldiers felt threatened by the civilians. Conclusion In summary, it is the peoples discontent that led to the resistance to the rules that the colonial masters wanted to impose on the people. However, the killing of the unarmed Protestants was regrettable. Thus, if the soldiers were provoked and no threat occurred in their lives, they were guilty for a charge of manslaughter. Finally, the judges verdict was inclined to one side, in support of the soldiers. Buy custom Boston Massacre essay

Nikes Dispute With The University Of Oregon Example

Nikes Dispute With The University Of Oregon Example Nike's Dispute With The University Of Oregon – Article Example Nike’s dispute with the of Oregon At the center of Nike’s dispute with the of Oregon were ethical business practices with emphasis on organizational accountability on wage rates, working environment and social corporate responsibility. Nike had support for the Fair Labor Association (FLA) which had legal and ethical loopholes that could still help multinationals gain through exploitative labor conditions and wage rates outside the United States. On the other hand University of Oregon joined in the spirit of solidarity with other universities to champion for Worker Rights Consortium (WRC) which fought to ensure strict adherence to human work condition for all the multinationals that sought their market in Apparel and sports kit. It is evident that WRC sought to eliminate the stakeholders’ interest among firms in the Apparel industry and this was seen by Nike as betrayal by its perennial benefactor in philanthropic financial donations.According to Friedman’s and Freeman’s theories, shareholder wealth maximization is the primary goal of a firm. In this regard managers ensure that firms operate under the protections of limited liability. The essence in this case is seen in how such a goal allows companies to privatize their gains while externalizing losses. Some of the tactics used by the company to achieve the goal include limited expenditure on safety workplace environment and low wages which sums up to be the bone of contention between Nike and University of Oregon. Nike therefore withdrew its support to University of Oregon as it saw the opportunity of manipulating minimum wage and other local, international and industrial labor laws was not achievable in the presence of Worker Rights Consortium.

What would you say to a comment that Romeo and Juliet is irrelevant to Essay

What would you say to a comment that Romeo and Juliet is irrelevant to the modern world - Essay Example After all, issues dealt with by young people of the Middle Ages could hardly have known the various pressures and issues facing the youth of the modern world, complete with dangerous drugs, significant family problems or gang violence. However, anyone remotely familiar with the play will quickly recognize these very modern issues within the action of the play. The play opens with a sense of gang wars as the men of Capulet meet with the men of Montague in the streets of Verona. As Gregory and Sampson talk among themselves, it is clear that they have nothing but evil intent for anyone associated with the house of Montague: â€Å"When I have fought with the men, I will be cruel with the maids, and cut off their heads† (I, i). As the conversation continues, it becomes clear that a play on words is intended here in which Sampson promises to fight, and kill if possible, the men of the rival ‘gang’ and rape their women, or kill them, depending upon how the mood strikes him. When they see two servants of the Montague household, the scene quickly escalates into a fight, which eventually draws in the younger members of the family, the citizens of the street and eventually summons the heads of household as well as the prince of the city to the scene. This sequence of events sounds very similar to the escalation of gang wars in wh ich murders are committed on either side, with guns rather than swords, until the gang leaders and the community are involved and the police attempt to restore order. Family problems are also illustrated throughout the play. Although Juliet isn’t raised in a single family household, she is isolated from her parents and the rest of her community. The nurse’s ramblings at the beginning of Act 1, scene 3 reveals that Lady Capulet didn’t nurse her own child. As was the practice of the day, Juliet had a wet-nurse, who has served her in the capacity of a mother

Materials selection for made umbrella Coursework

Materials selection for made umbrella - Coursework Example Other parts include the spring, the runner and the finial or ferrule. This paper will discuss the materials suitable for making the pole or shaft, the canopy, and the ribs. The pole is the metallic or wooden shaft that connects the handle to the canopy. The shaft should be strong enough to withstand different forces such as part of the weight of the user (if used as a walking stick), and to avoid breaking during windy conditions. The shaft of the umbrella should be rust resistant as it commonly gets into contact with rain water. The shaft should also be made of a material that is light so that the overall weight of the umbrella is bearable. One material that is suitable for use in making the umbrella shaft is aluminium. Aluminium is more suitable for use as an umbrella shaft compared to steel, wood and other materials for several reasons. First, compared to wood, it is not affected by moisture making it suitable during rainy days (Ashby, Rayner, & Hunkin 2012). It also does not rot or gets eaten by pests such as termites, and it can withstand changes in temperature without bending or loosing shape. Compared to steel, it is light in weight and is not su bject to rust, making it more durable and long-lasting (Ashby, Rayner, & Hunkin 2012). In terms of cost, aluminium is relatively inexpensive and readily available. The canopy is the part of the umbrella that serves to keep away the rain or shield the user from sunshine. The canopy should be made of a light material that is foldable. The materials should also be washable if its get dirty. The material used to make the canopy should not be one that gets easily destroyed by water or ultraviolet rays. Most important is that the material should be water proof so that the user does not get wet in the rain. One material that is suitable for use in making the canopy is the canopy is nylon taffeta. Nylon is water proof and more durable compared to cotton and other materials